SoluFlex Link™

Features of the
SoluFlex Link™ Hydrophilic Linkers

Our new linker structure allows for ADCs with a DAR¹ of 8 and achieves hydrophilicity comparable to unconjugated antibodies.
This new branched linker structure with high hydrophilicity minimizes the solution exposure of hydrophobic payloads.

• Compatible with all cleavable and non-cleavable linkers and payloads (Branched linker flexibility)
• Improved hydrophilicity (Superior to PEG in hydrophilic properties)
• Optimized pharmacokinetic (PK) profile
• Low immunogenicity potential
• High conjugation and purification yields
• Thermal stability, freeze/thaw stability
• Target dependent in vitro efficacy
• No toxic metabolites

• 1.DAR : Drug-to-antibody ratio
• 2.Poly Ethylene Glycol
• 3.Using Exatecan-Topo 1 inhibitor drug

LOTTE Biologics leverages its ADC platform to offer a broad range of linker-payload options through its ADC Toolbox service.
We have designed an optimized ADC Toolbox that enables the selection of lead candidate linker- payload combinations, supporting successful ADC development and accelerating our clients' path to the clinic.